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The malabsorption syndrome is a constellation of symptoms and signs that are the result of an abnormal net transfer of substrate from the intestinal lumen to the body. In the broad sense, malabsorption describes not only a decrease in the absorption of exogenous substrate,. but also an increase in the loss of endogenous substrates into the gut lumen. The process may be generalized and include many if not all substrates, such as fat, soluble vitamins, carbohydrate, protein, minerals, other vitamins and water, or it may be specific to a single substrate. The clinical significance and the substrate pecificity are determined by the nature, location, and extent of the lesion. A case of maldigestion, 44 years old male chronic alcoholic with chronic pancreatitis who had large benign gastric ulcer operated on, and a case of blind loop syndrome, 33 years old male. Who had gastrojejuno-colic fistula after simple gastrojejunostomy for the treament of duodenal ulcer, was compared for the evaluation of malabsorptron studies, and also detailed approach methods for the diff ential diagnosis of malabsorption syndromes were disscussed
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